diff --git a/fire/core.py b/fire/core.py
index 8e23e76b..81755393 100644
--- a/fire/core.py
+++ b/fire/core.py
@@ -50,6 +50,7 @@ def main(argv):
 """
 
 import asyncio
+import concurrent.futures
 import inspect
 import json
 import os
@@ -649,6 +650,30 @@ def _GetMember(component, args):
   raise FireError('Could not consume arg:', arg)
 
 
+def _RunCoroutine(coro):
+  """Runs a coroutine, blocking until it completes.
+
+  Args:
+    coro: The coroutine to run.
+
+  Returns:
+    The value the coroutine returns.
+
+  Raises:
+    Exception: Whatever the coroutine raises.
+  """
+  try:
+    asyncio.get_running_loop()
+  except RuntimeError:
+    return asyncio.run(coro)
+  # asyncio.run refuses to be called while this thread already runs a loop,
+  # which happens when Fire is called from async code. Drive the coroutine
+  # from a loop belonging to a worker thread instead, so the call still
+  # blocks here until the coroutine completes.
+  with concurrent.futures.ThreadPoolExecutor(max_workers=1) as pool:
+    return pool.submit(asyncio.run, coro).result()
+
+
 def _CallAndUpdateTrace(component, args, component_trace, treatment='class',
                         target=None):
   """Call the component by consuming args from args, and update the FireTrace.
@@ -678,14 +703,7 @@ def _CallAndUpdateTrace(component, args, component_trace, treatment='class',
 
   # Call the function.
   if inspectutils.IsCoroutineFunction(fn):
-    try:
-      loop = asyncio.get_running_loop()
-    except RuntimeError:
-      # No event loop running, create a new one
-      component = asyncio.run(fn(*varargs, **kwargs))
-    else:
-      # Event loop is already running
-      component = loop.run_until_complete(fn(*varargs, **kwargs))
+    component = _RunCoroutine(fn(*varargs, **kwargs))
   else:
     component = fn(*varargs, **kwargs)
 
diff --git a/fire/fire_test.py b/fire/fire_test.py
index 99b4a7c6..6956a72c 100644
--- a/fire/fire_test.py
+++ b/fire/fire_test.py
@@ -14,6 +14,7 @@
 
 """Tests for the fire module."""
 
+import asyncio
 import os
 import sys
 from unittest import mock
@@ -716,6 +717,23 @@ def testFireAsyncio(self):
     self.assertEqual(fire.Fire(tc.py3.WithAsyncio,
                                command=['double', '--count', '10']), 20)
 
+  def testFireAsyncioFromRunningLoop(self):
+    async def main():
+      return fire.Fire(tc.py3.WithAsyncio,
+                       command=['double', '--count', '10'])
+
+    self.assertEqual(asyncio.run(main()), 20)
+
+  def testFireAsyncioFromRunningLoopRaises(self):
+    async def raiser(count=0):
+      raise ValueError('boom')
+
+    async def main():
+      return fire.Fire(raiser, command=['--count', '3'])
+
+    with self.assertRaises(ValueError):
+      asyncio.run(main())
+
 
 if __name__ == '__main__':
   testutils.main()