diff --git a/.github/workflows/python.yml b/.github/workflows/python.yml
index c7602893..c0efd0c4 100644
--- a/.github/workflows/python.yml
+++ b/.github/workflows/python.yml
@@ -50,7 +50,7 @@ jobs:
     strategy:
       matrix:
         os: [ubuntu-latest, ubuntu-24.04-arm, macos-latest]
-        python-version: ["3.10", "3.11", "3.12", "3.13", "3.13t", "3.14", "3.14t", "3.15", "3.15t"]
+        python-version: ["3.11", "3.12", "3.13", "3.13t", "3.14", "3.14t", "3.15", "3.15t"]
         openslide: [system, wheel]
         include:
           - os: ubuntu-latest
@@ -170,7 +170,7 @@ jobs:
         shell: bash
     strategy:
       matrix:
-        python-version: ["3.10", "3.11", "3.12", "3.13", "3.13t", "3.14", "3.14t", "3.15", "3.15t"]
+        python-version: ["3.11", "3.12", "3.13", "3.13t", "3.14", "3.14t", "3.15", "3.15t"]
         openslide: [zip, wheel]
     steps:
     - name: Check out repo
@@ -238,27 +238,6 @@ jobs:
         path: artifacts/whl
         compression-level: 0
 
-  setuptools:
-    name: Setuptools install
-    needs: pre-commit
-    runs-on: ubuntu-latest
-    container: ubuntu:22.04
-    steps:
-    - name: Install dependencies
-      run: |
-        apt-get update
-        DEBIAN_FRONTEND=noninteractive apt-get install -y \
-            git libopenslide0 python3-jinja2 python3-pil python3-pip
-        pip install pytest
-    - name: Check out repo
-      uses: actions/checkout@v7
-    - name: Install OpenSlide Python
-      run: python3 setup.py install
-    - name: Run tests
-      run: pytest -v
-    - name: Tile slide
-      run: python3 examples/deepzoom/deepzoom_tile.py --viewer -o tiled tests/fixtures/small.svs
-
   docs:
     name: Docs
     needs: pre-commit
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index d2c0fc91..f0cc91b2 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -40,7 +40,7 @@ repos:
         name: Check Python types
         priority: 0
         # Pillow is ignored in dependabot.yml
-        additional_dependencies: [flask, openslide-bin, pillow >= 13.0.0, types-PyYAML, types-setuptools]
+        additional_dependencies: [flask, openslide-bin, pillow >= 12.1.0, types-PyYAML, types-setuptools]
 
   - repo: https://github.com/rstcheck/rstcheck
     rev: v6.3.0
@@ -56,8 +56,6 @@ repos:
       - id: codespell
         name: Check spelling with codespell
         priority: 0
-        additional_dependencies:
-          - tomli  # Python < 3.11
 
   - repo: meta
     hooks:
diff --git a/README.md b/README.md
index e9e21352..a6652ee7 100644
--- a/README.md
+++ b/README.md
@@ -45,7 +45,7 @@ OpenSlide can read virtual slides in several formats:
 
 ## Requirements
 
-* Python ≥ 3.10
+* Python ≥ 3.11
 * OpenSlide ≥ 3.4.0
 * Pillow
 
diff --git a/openslide/__init__.py b/openslide/__init__.py
index f8c6e367..b4dd5deb 100644
--- a/openslide/__init__.py
+++ b/openslide/__init__.py
@@ -28,7 +28,7 @@
 from collections.abc import Iterator, Mapping
 from io import BytesIO
 from types import TracebackType
-from typing import Literal, TypeVar
+from typing import Literal, Self, TypeVar
 
 from PIL import Image, ImageCms
 
@@ -66,7 +66,7 @@ class AbstractSlide(metaclass=ABCMeta):
     def __init__(self) -> None:
         self._profile: bytes | None = None
 
-    def __enter__(self: _T) -> _T:
+    def __enter__(self) -> Self:
         return self
 
     def __exit__(
@@ -178,9 +178,7 @@ def get_thumbnail(self, size: tuple[int, int]) -> Image.Image:
         bg_color = '#' + self.properties.get(PROPERTY_NAME_BACKGROUND_COLOR, 'ffffff')
         thumb = Image.new('RGB', tile.size, bg_color)
         thumb.paste(tile, None, tile)
-        # Image.Resampling added in Pillow 9.1.0
-        # Image.LANCZOS removed in Pillow 10
-        thumb.thumbnail(size, getattr(Image, 'Resampling', Image).LANCZOS)
+        thumb.thumbnail(size, Image.Resampling.LANCZOS)
         if self._profile is not None:
             thumb.info['icc_profile'] = self._profile
         return thumb
@@ -392,8 +390,7 @@ def detect_format(cls, filename: lowlevel.Filename) -> str | None:
         If the file format is not recognized, return None."""
         try:
             with Image.open(filename) as img:
-                # mypy will think img is Any until we drop Python 3.10
-                return img.format  # type: ignore[no-any-return]
+                return img.format
         except OSError:
             return None
 
diff --git a/openslide/deepzoom.py b/openslide/deepzoom.py
index 9eb89dea..afa5bf6d 100644
--- a/openslide/deepzoom.py
+++ b/openslide/deepzoom.py
@@ -185,9 +185,7 @@ def get_tile(self, level: int, address: tuple[int, int]) -> Image.Image:
 
         # Scale to the correct size
         if tile.size != z_size:
-            # Image.Resampling added in Pillow 9.1.0
-            # Image.LANCZOS removed in Pillow 10
-            tile.thumbnail(z_size, getattr(Image, 'Resampling', Image).LANCZOS)
+            tile.thumbnail(z_size, Image.Resampling.LANCZOS)
 
         # Reference ICC profile
         if profile is not None:
diff --git a/pyproject.toml b/pyproject.toml
index 532231ff..01891899 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -18,7 +18,6 @@ classifiers = [
     "Operating System :: POSIX :: Linux",
     "Programming Language :: Python",
     "Programming Language :: Python :: 3",
-    "Programming Language :: Python :: 3.10",
     "Programming Language :: Python :: 3.11",
     "Programming Language :: Python :: 3.12",
     "Programming Language :: Python :: 3.13",
@@ -28,7 +27,7 @@ classifiers = [
     "Topic :: Scientific/Engineering :: Bio-Informatics",
     "Typing :: Typed",
 ]
-requires-python = ">= 3.10"
+requires-python = ">= 3.11"
 dependencies = ["Pillow"]
 dynamic = ["version"]
 
@@ -58,7 +57,7 @@ check-hidden = true
 # ignore-words-list = ""
 
 [tool.mypy]
-python_version = "3.10"
+python_version = "3.11"
 strict = true
 
 [tool.pytest.ini_options]
diff --git a/setup.py b/setup.py
index dbdca38d..21c75f6f 100644
--- a/setup.py
+++ b/setup.py
@@ -1,18 +1,13 @@
-from pathlib import Path
 import sys
 import sysconfig
 
 from setuptools import Extension, setup
 from setuptools import __version__ as _setuptools_ver
 
-# Load version string
-with open(Path(__file__).parent / 'openslide/_version.py') as _fh:
-    exec(_fh.read())  # instantiates __version__  # noqa: S102
-
 # Use the free-threaded Stable ABI (abi3t) only on free-threaded Python
 # 3.15+ with setuptools 84.2+; Python supports building abi3t from
 # GIL-enabled interpreters but setuptools doesn't yet.  Use the
-# non-free-threaded Stable API (abi3) on Python 3.11+ with GIL enabled, and
+# non-free-threaded Stable API (abi3) with GIL enabled, and
 # release-specific wheels in all other cases.
 _freethread = sysconfig.get_config_var('Py_GIL_DISABLED')
 _abi3t = (
@@ -20,7 +15,7 @@
     and _freethread
     and tuple(int(c) for c in _setuptools_ver.split('.')) >= (84, 2)
 )
-_abi3 = sys.version_info >= (3, 11) and not _freethread
+_abi3 = not _freethread
 
 setup(
     ext_modules=[
@@ -45,18 +40,4 @@
         if _abi3
         else {},
     },
-    #
-    # setuptools < 61 compatibility for distro packages building from source
-    name='openslide-python',
-    version=__version__,  # type: ignore[name-defined]  # noqa: F821
-    install_requires=[
-        'Pillow',
-    ],
-    packages=[
-        'openslide',
-    ],
-    package_data={
-        'openslide': ['py.typed', '*.pyi'],
-    },
-    zip_safe=False,
 )